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Dynamin I (phospho Ser774) rabbit pAb

CAT: 0855-ES5010-01Size: 50 µLDry Ice: NoHazardous: No
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Background
Dynamin 1 (DNM1) Homo sapiens This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Description
Dynamin 1 (DNM1) Homo sapiens This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008],
UniProt
Q05193
Swiss Prot
Q05193
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human Dynamin-1 around the phosphorylation site of Ser774. AA range:740-789
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Molecular Weight
97kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
97kD
Fragment
IgG
Subcellular Location
Cytoplasm . Cytoplasm, cytoskeleton . Microtubule-associated.
Other Product Names
DNM1; DNM; Dynamin-1
Gene ID (Human)
1759

UniProtKB · Q05193

Dynamin-1

DYN1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q05193
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
DNM1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.6.5.5
Processing
—
Secondary accessions
A6NLM6, Q5SYX0, Q5SYX2, Q6P3T6, Q86VD2
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneCell projectionCoated pitCytoplasmic vesicleMembraneMicrotubuleSynapse

Disease

Disease variantEpilepsy

Biological process

Endocytosis

Ligand

GTP-bindingNucleotide-binding

Molecular function

HydrolaseMotor protein

PTM

MethylationNitrationPhosphoprotein

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MBS502028-01Anti-Phospho-Ser774 Dynamin
XPS-1006Dynamin (phospho Ser774) Antibody
OAPC00153-100ULDynamin Antibody (Phospho-Ser774)
GWB-74AA41Dynamin Antibody (phospho Ser774)
E47R13039Phospho-Dynamin 1 (Ser774) Rabbit pAb
AF3396-BPPhospho-Dynamin 1 (Ser774) Peptide
MBS9502419-01Dynamin-1 (Phospho-Ser774) Antibody
ABF3396Phospho-Dynamin-1 (Ser774) Antibody
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