Products for Research Use Only
RegisterLogin

HP1γ (phospho Ser93) rabbit pAb

CAT: 0855-ES4639-01Size: 50 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0855-ES4639-01Size:50 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.[provided by RefSeq, Mar 2011]
Description
At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene. [provided by RefSeq, Mar 2011],
UniProt
Q13185
Swiss Prot
Q13185
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human HP1 gamma around the phosphorylation site of Ser93. AA range:59-108
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Molecular Weight
24kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
24kD
Fragment
IgG
Subcellular Location
Nucleus . Associates with euchromatin and is largely excluded from constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis (Potential) . .
Other Product Names
CBX3; Chromobox protein homolog 3; HECH; Heterochromatin protein 1 homolog gamma; HP1 gamma; Modifier 2 protein
Gene ID (Human)
11335/653972

UniProtKB · Q13185

Chromobox protein homolog 3

CBX3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q13185
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CBX3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q96CD7, Q99409, Q9BVS3, Q9P0Z6
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Biological process

Biological rhythmsTranscriptionTranscription regulation

Molecular function

Chromatin regulatorRepressor

Cellular component

Nucleus

Domain

Repeat

Related Products

CatalogName
ES5346-01HP1α (phospho Ser92) rabbit pAb
ES15682-01HP1γ (phospho-Ser83) rabbit pAb
ES18075-01Beclin-1 (phospho-Ser93) rabbit pAb
ES4638-01HP1γ rabbit pAb
ES2563-01HP1α rabbit pAb
ES5734-01DREAM (phospho Ser63) rabbit pAb
ES12362-01Vimentin (phospho-Ser39) rabbit pAb
ES1325-01HDAC8 (phospho Ser39) rabbit pAb
ES6876-01Bad (phospho Ser91) rabbit pAb
ES4579-01KIF2C (phospho Ser95) rabbit pAb

Alternative Products

CatalogName
ABM0531HP1γ (Phospho-Ser93) Antibody
79-879HP1γ (phospho Ser93) Antibody
P40469-01Rabbit Polyclonal Antibody to HP1γ (Phospho-Ser93)
APRab04792-01HP1γ (phospho Ser93) Rabbit Polyclonal Antibody
E47R3221Phospho-HP1 gamma (Ser93) Rabbit pAb
MBS9503321-01HP1 gamma (Phospho-Ser93) Antibody
E44H00991HP1γ (phospho Ser93) Polyclonal Antibody
EKA51656Phospho-HP1γ (Ser93) ELISA Kit
SL3221R-01Rabbit Anti-Phospho-HP1 gamma (Ser93) antibody
MBS8520224-01HP1 gamma (phospho Ser93) Polyclonal Antibody

Popular Products