MKP-5 rabbit pAb

• Background:

  Dual specificity phosphatase 10 (DUSP10) Homo sapiens Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

• Description:

  Dual specificity phosphatase 10 (DUSP10) Homo sapiens Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014],

• Synonyms:

  DUSP10; MKP5; Dual specificity protein phosphatase 10; Mitogen-activated protein kinase phosphatase 5; MAP kinase phosphatase 5; MKP-5

• Gene ID:

  11221

• UniProt:

  Q9Y6W6

• Cellular Locus:

  Cytoplasm. Nucleus.

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse, Rat

• Reactivity:

  Human; Mouse; Rat

• Immunogen:

  Synthesized peptide derived from MKP-5 . at AA range: 330-410

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Source:

  Rabbit

• Applications:

  WB, ELISA, IHC

• Validated Applications:

  WB, ELISA, IHC

• Stability:

  -20°C/1 year

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000

• Molecular Weight:

  52kD

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

• Observed Molecular Weight:

  52 kD

• Subcellular Location:

  Cytoplasm. Nucleus.

• Other Product Names:

  DUSP10; MKP5; Dual specificity protein phosphatase 10; Mitogen-activated protein kinase phosphatase 5; MAP kinase phosphatase 5; MKP-5

• Gene ID (Human):

  11221

• SwissProt (Human):

  Q9Y6W6