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MLC-2 rabbit pAb

CAT: 0855-ES4526-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES4526-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a nonsarcomeric myosin regulatory light chain. This protein is activated by phosphorylation and regulates smooth muscle and non-muscle cell contraction. This protein may also be involved in DNA damage repair by sequestering the transcriptional regulator apoptosis-antagonizing transcription factor (AATF) /Che-1 which functions as a repressor of p53-driven apoptosis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8.[provided by RefSeq, Dec 2014]
Description
This gene encodes a nonsarcomeric myosin regulatory light chain. This protein is activated by phosphorylation and regulates smooth muscle and non-muscle cell contraction. This protein may also be involved in DNA damage repair by sequestering the transcriptional regulator apoptosis-antagonizing transcription factor (AATF)/Che-1 which functions as a repressor of p53-driven apoptosis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8. [provided by RefSeq, Dec 2014],
UniProt
P19105/O14950/P24844
Swiss Prot
P19105/O14950/P24844
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human MLC-2. AA range:5-54
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 , Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Stress fiber, cytosol, brush border, myosin complex, myosin II complex, Z disc, apical part of cell, extracellular exosome
Other Product Names
MYL12A; MLCB; MRLC3; RLC; Myosin regulatory light chain 12A; MLC-2B; Myosin RLC; Myosin regulatory light chain 2; nonsarcomeric; Myosin regulatory light chain MRLC3; MYL12B; MRLC2; MYLC2B; Myosin regulatory light chain 12B; MLC-2A; MLC-2; M
Gene ID (Human)
10398/10627

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