Cdk7 (phospho Thr170) rabbit pAb

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Background

Cyclin dependent kinase 7 (CDK7) Homo sapiens The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK) . It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. [provided by RefSeq, Jul 2008]

Description

Cyclin dependent kinase 7 (CDK7) Homo sapiens The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. [provided by RefSeq, Jul 2008],

UniProt

P50613

Swiss Prot

P50613

Reactivity

Human; Mouse

Immunogen

The antiserum was produced against synthesized peptide derived from human CDK7 around the phosphorylation site of Thr170. AA range:136-185

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC; IF; ELISA

Concentration

1 mg/ml

Dilution

Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

Molecular Weight

40kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

40kD

Fragment

IgG

Subcellular Location

Nucleus . Cytoplasm . Cytoplasm, perinuclear region . Colocalizes with PRKCI in the cytoplasm and nucleus (PubMed:15695176) . Translocates from the nucleus to cytoplasm and perinuclear region in response to DNA-bound peptides (PubMed:19071173) . .

Other Product Names

CDK7; CAK; CAK1; CDKN7; MO15; STK1; Cyclin-dependent kinase 7; 39 kDa protein kinase; p39 Mo15; CDK-activating kinase 1; Cell division protein kinase 7; Serine/threonine-protein kinase 1; TFIIH basal transcription factor complex kinase subu

Gene ID (Human)

1022

UniProtKB · P50613

Cyclin-dependent kinase 7

CDK7_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P50613
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: CDK7
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: 2.7.11.22, 2.7.11.23
Processing: —
Secondary accessions: Q9BS60, Q9UE19

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Ligand

ATP-bindingNucleotide-binding

Biological process

Cell cycleCell divisionDNA damageDNA repairTranscriptionTranscription regulation

Cellular component

CytoplasmNucleus

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

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Alternative Products

Catalog	Name
APP1213-01	Phospho-Cdk7 (Thr170) Rabbit pAb
MBS858851-01	CDK7 (Phospho-Thr170) Antibody
A0857-01	Cdk7 (phospho Thr170) Antibody
OASG01454-100UL	CDK7 Antibody (Phospho-Thr170)
GTR17709903-01	Phospho-CDK7 (Thr170) Rabbit Polyclonal Antibody
E28PP0731	Cdk7 (phospho Thr170) Rabbit Polyclonal Antibody
BS43296-01	Phospho-Cdk7 (Thr170) Recombinant Rabbit mAb
SL10997R-01	Rabbit Anti-phospho-CDK7 (Thr170) antibody
MBS9459149-01	Cdk7 (Phospho Thr170) Polyclonal Antibody
bs-10997R-TR	Phospho-CDK7 (Thr170) Polyclonal Antibody