CD98 rabbit pAb

• Background:

  This gene is a member of the solute carrier family and encodes a cell surface, transmembrane protein. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. The encoded transporter plays a role in regulation of intracellular calcium levels and transports L-type amino acids. Alternatively spliced transcript variants, encoding different isoforms, have been characterized. [provided by RefSeq, Nov 2010]

• Description:

  This gene is a member of the solute carrier family and encodes a cell surface, transmembrane protein. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. The encoded transporter plays a role in regulation of intracellular calcium levels and transports L-type amino acids. Alternatively spliced transcript variants, encoding different isoforms, have been characterized. [provided by RefSeq, Nov 2010],

• UniProt:

  P08195

• Swiss Prot:

  P08195

• Reactivity:

  Human; Mouse; Rat

• Immunogen:

  The antiserum was produced against synthesized peptide derived from the C-terminal region of human SLC3A2. AA range:491-540

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  WB; ELISA

• Concentration:

  1 mg/ml

• Dilution:

  Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

• Molecular Weight:

  69kD

• Storage Conditions:

  -20°C/1 year

• Observed Molecular Weight:

  69kD

• Fragment:

  IgG

• Subcellular Location:

  Apical cell membrane . Cell membrane ; Single-pass type II membrane protein . Cell junction . Lysosome membrane . Melanosome . Localized at the plasma membrane when associated with SLC7A5/LAT1 or SLC7A8/LAT2 (PubMed:9751058, PubMed:11311135) . Localized to the apical membrane of placental syncytiotrophoblastic cells (PubMed:11742812) . Recruited to lysosomes by LAPTM4B (PubMed:25998567) . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065) . Located selectively at cell-cell adhesion sites (By similarity) . Colocalized with SLC7A8/LAT2 at the basolateral membrane of kidney proximal tubules and small intestine epithelia. Expressed in both luminal and abluminal membranes of brain capillary endothelial cells (By similarity) . .

• Other Product Names:

  SLC3A2; MDU1; 4F2 cell-surface antigen heavy chain; 4F2hc; 4F2 heavy chain antigen; Lymphocyte activation antigen 4F2 large subunit; CD98

• Gene ID (Human):

  6520