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PSGL-1 rabbit pAb

CAT: 0855-ES4302-02Size: 100 µLDry Ice: NoHazardous: No
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Background
This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]
Description
This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2011],
Product Name Alternative
SELPLG; P-selectin glycoprotein ligand 1; PSGL-1; Selectin P ligand; CD162
UniProt
Q14242
Swiss Prot
Q14242
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from the N-terminal region of human SELPLG. AA range:1-50
Target
PSGL-1
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
45 110kd(glycosylated)
Storage Conditions
-20°C/1 year
Observed Molecular Weight
45 110kd (glycosylated)
Fragment
IgG
Subcellular Location
Membrane; Single-pass type I membrane protein.
Other Product Names
SELPLG; P-selectin glycoprotein ligand 1; PSGL-1; Selectin P ligand; CD162
Gene ID (Human)
6404

UniProtKB · Q14242

P-selectin glycoprotein ligand 1

SELPL_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q14242
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SELPLG
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
PSGL-1
EC number
—
Processing
Precursor
Secondary accessions
A8K2Y0, B4DQC3, B7Z5C7, J3KMX6, Q12775, Q6GTW7, Q8N7J7
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Cell adhesionHost-virus interaction

PTM

Cleavage on pair of basic residuesDisulfide bondGlycoproteinPhosphoproteinPyrrolidone carboxylic acidSulfation

Molecular function

Host cell receptor for virus entryReceptor

Cellular component

Membrane

Domain

RepeatSignalTransmembraneTransmembrane helix

Ligand

Sialic acid

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