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TPO rabbit pAb

CAT: 0855-ES4143-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES4143-01Size:50 µL
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Background
Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5' UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent. [provided by RefSeq, Feb 2014]
Description
Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5' UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent. [provided by RefSeq, Feb 2014],
Product Name Alternative
THPO; MGDF; Thrombopoietin; C-mpl ligand; ML; Megakaryocyte colony-stimulating factor; Megakaryocyte growth and development factor; MGDF; Myeloproliferative leukemia virus oncogene ligand
UniProt
P40225
Swiss Prot
P40225
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human THPO. AA range:41-90
Target
TPO
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
38kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
38kD
Fragment
IgG
Subcellular Location
Secreted.
Other Product Names
THPO; MGDF; Thrombopoietin; C-mpl ligand; ML; Megakaryocyte colony-stimulating factor; Megakaryocyte growth and development factor; MGDF; Myeloproliferative leukemia virus oncogene ligand
Gene ID (Human)
7066

UniProtKB · P40225

Thrombopoietin

TPO_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P40225
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
THPO
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A1L3Y0, B7ZLR8, B9EGA8, Q13020, Q15790, Q15791, Q15792
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Molecular function

CytokineHormone

Disease

Disease variant

PTM

Disulfide bondGlycoprotein

Cellular component

Secreted

Domain

Signal

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