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SHIP-2 rabbit pAb

CAT: 0855-ES3956-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES3956-02Size:100 µL
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Background
The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer. [provided by RefSeq, Jan 2009]
Description
The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer. [provided by RefSeq, Jan 2009],
UniProt
O15357
Swiss Prot
O15357
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human INPPL1. AA range:351-400
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.
Molecular Weight
130kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
130kD
Fragment
IgG
Subcellular Location
Cytoplasm, cytosol . Cytoplasm, cytoskeleton. Membrane ; Peripheral membrane protein. Cell projection, filopodium . Cell projection, lamellipodium . Nucleus . Nucleus speckle . Translocates to membrane ruffles when activated, translocation is probably due to different mechanisms depending on the stimulus and cell type. Partly translocated via its SH2 domain which mediates interaction with tyrosine phosphorylated receptors such as the FC-gamma-RIIB receptor (FCGR2B) . Tyrosine phosphorylation may also participate in membrane localization. Insulin specifically stimulates its redistribution from the cytosol to the plasma membrane. Recruited to the membrane following M-CSF stimulation. In activated spreading platelets, localizes with actin at filopodia, lamellipodia and the central actin ring.
Other Product Names
INPPL1; SHIP2; Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2; Inositol polyphosphate phosphatase-like protein 1; INPPL-1; Protein 51C; SH2 domain-containing inositol 5'-phosphatase 2; SH2 domain-containing inositol phosphatase 2; SHIP-2
Gene ID (Human)
3636

UniProtKB · O15357

Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

SHIP2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O15357
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
INPPL1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.1.3.86
Processing
—
Secondary accessions
B2RTX5, Q13577, Q13578
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

Actin-bindingHydrolase

Coding sequence diversity

Alternative splicing

Biological process

Cell adhesionImmunityLipid metabolism

Cellular component

Cell membraneCell projectionCytoplasmCytoskeletonMembraneNucleus

Disease

Diabetes mellitusDisease variant

Ligand

MagnesiumMetal-binding

PTM

Phosphoprotein

Domain

SH2 domainSH3-binding

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