MARK1/2/3/4 rabbit pAb

• Background:

  Catalytic activity:ATP + a protein = ADP + a phosphoprotein., cofactor:Magnesium., enzyme regulation:Activated by phosphorylation on Thr-215 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39., function:May play a role in cytoskeletal stability., similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. MARK subfamily., similarity:Contains 1 KA1 (kinase-associated) domain., similarity:Contains 1 protein kinase domain., similarity:Contains 1 UBA domain., subcellular location:Appears to localize to an intracellular network., tissue specificity:Highly expressed in heart, skeletal muscle, brain, fetal brain and fetal kidney.

• Description:

  Catalytic activity: ATP + a protein = ADP + a phosphoprotein. Cofactor: Magnesium. enzyme regulation: Activated by phosphorylation on Thr-215 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39. function: May play a role in cytoskeletal stability. similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. MARK subfamily. similarity: Contains 1 KA1 (kinase-associated) domain. similarity: Contains 1 protein kinase domain. similarity: Contains 1 UBA domain. subcellular location: Appears to localize to an intracellular network. tissue specificity: Highly expressed in heart, skeletal muscle, brain, fetal brain and fetal kidney.

• Synonyms:

  MARK1; KIAA1477; MARK; Serine/threonine-protein kinase MARK1; MAP/microtubule affinity-regulating kinase 1; PAR1 homolog c; Par-1c; Par1c; MARK2; EMK1; Serine/threonine-protein kinase MARK2; ELKL motif kinase 1; EMK-1; MAP/microtubule affin

• Gene ID:

  4139/2011/4140/57787

• UniProt:

  Q9P0L2/Q7KZI7/P27448/Q96L34

• Cellular Locus:

  Cell membrane ; Peripheral membrane protein. Cytoplasm, cytoskeleton. Cytoplasm. Cell projection, dendrite. Appears to localize to an intracellular network..

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse, Rat, Monkey

• Reactivity:

  Human; Mouse; Rat; Monkey

• Immunogen:

  The antiserum was produced against synthesized peptide derived from human MARK1/2/3/4. AA range:181-230

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Source:

  Rabbit

• Applications:

  WB; IHC; IF; ELISA

• Validated Applications:

  WB, IHC, IF, ELISA

• Stability:

  -20°C / 1 year

• Concentration:

  1 mg/mL

• Dilution:

  Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.

• Molecular Weight:

  89kD

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

• Observed Molecular Weight:

  89kD

• Subcellular Location:

  Cell membrane ; Peripheral membrane protein . Cytoplasm, cytoskeleton . Cytoplasm . Cell projection, dendrite . Appears to localize to an intracellular network. .

• Other Product Names:

  MARK1; KIAA1477; MARK; Serine/threonine-protein kinase MARK1; MAP/microtubule affinity-regulating kinase 1; PAR1 homolog c; Par-1c; Par1c; MARK2; EMK1; Serine/threonine-protein kinase MARK2; ELKL motif kinase 1; EMK-1; MAP/microtubule affin

• Gene ID (Human):

  4139/2011/4140/57787

• SwissProt (Human):

  Q9P0L2/Q7KZI7/P27448/Q96L34