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Integrin β4 rabbit pAb

CAT: 0855-ES2632-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES2632-02Size:100 µL
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Background
Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Description
Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
UniProt
P16144
Swiss Prot
P16144
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human Integrin beta4. AA range:1481-1530
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Molecular Weight
202kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
202kD
Fragment
IgG
Subcellular Location
Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor. Cell junction, hemidesmosome. Colocalizes with DST at the leading edge of migrating keratinocytes.
Other Product Names
ITGB4; Integrin beta-4; GP150; CD antigen CD104
Gene ID (Human)
3691

UniProtKB · P16144

Integrin beta-4

ITB4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P16144
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ITGB4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A0AVL6, O14690, O14691, O15339, O15340, O15341, Q0VF97, Q9UIQ4
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

CalciumMagnesiumMetal-binding

Biological process

Cell adhesion

Cellular component

Cell junctionCell membraneMembrane

Disease

Disease variantEpidermolysis bullosa

PTM

Disulfide bondGlycoproteinLipoproteinPalmitatePhosphoprotein

Domain

EGF-like domainRepeatSignalTransmembraneTransmembrane helix

Molecular function

IntegrinReceptor

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