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Histone H2A.X rabbit pAb

CAT: 0855-ES2525-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES2525-01Size:50 µL
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Background
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Oct 2015]
Description
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Oct 2015],
UniProt
P16104
Swiss Prot
P16104
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human Histone H2A.X. AA range:94-143
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; CoIP; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. IP 1:200-500, ELISA: 1/10000. Not yet tested in other applications.
Molecular Weight
19kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
19kD
Fragment
IgG
Subcellular Location
Nucleus . Chromosome .
Other Product Names
H2AFX; H2AX; Histone H2A.x; H2a/x
Gene ID (Human)
3014

UniProtKB · P16104

Histone H2AX

H2AX_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P16104
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
H2AX
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
H2a/x
EC number
—
Processing
—
Secondary accessions
Q4ZGJ7, Q6IAS5
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Biological process

Cell cycleDNA damageDNA recombinationDNA repairHost-virus interactionMeiosis

Cellular component

ChromosomeNucleosome coreNucleus

Molecular function

DNA-binding

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Alternative Products

CatalogName
APA2102-01Histone H2A.X Rabbit pAb
MBS8603900-01Histone H2A.X Rabbit mAb
abx121964-01Histone H2A.X (Histone H2A.X) Antibody
223239-01Histone H2A.X (Histone H2AX, H2a/x, Histone H2A.X, H2AFX, H2AX) discontinued
MBS614817-01Histone H2A.X (H2A histone family member X, H2A.FX, H2A/X, H2AFX)
MBS8534911-01Histone H2A.X
318950H2AFX (Histone H2A.X, H2A.X, H2A/X, H2AX)
H5110-03RHistone H2A.X (H2A Histone Family Member X, H2A.FX, H2A/X, H2AFX, H2AX, H2A.X) discontinued
MBS626095-01Histone H2A.X (H2A Histone Family Member X, H2A.FX, H2A/X, H2AFX, H2AX)
482473H2AFX (Histone H2A.x, H2A Histone Family, Member X)

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