Aldolase B rabbit pAb

CAT: 0855-ES1640-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0855-ES1640-01Size:50 µL

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Background

Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high

Description

Fructose-1, 6-bisphosphate aldolase (EC 4. 1. 2. 13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1, 6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high

UniProt

P05062

Swiss Prot

P05062

Reactivity

Human; Mouse; Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human ALDOB. AA range:111-160

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC; IF; ELISA

Concentration

1 mg/ml

Dilution

Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

Molecular Weight

39kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

39kD

Fragment

IgG

Subcellular Location

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite .

Other Product Names

ALDOB; ALDB; Fructose-bisphosphate aldolase B; Liver-type aldolase

Gene ID (Human)

229

UniProtKB · P05062

Fructose-bisphosphate aldolase B

ALDOB_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P05062
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: ALDOB
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: 4.1.2.13
Processing: —
Secondary accessions: Q13741, Q13742, Q5T7D6

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Cellular component

CytoplasmCytoskeleton

Disease

Disease variant

Biological process

Glycolysis

Molecular function

Lyase

Ligand

Schiff base

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Alternative Products

Catalog	Name
MBS8421136-01	Rabbit Aldolase Purified
F0875-01	Aldolase A Rabbit mAb
HY-P2726-01	Aldolase, Rabbit muscle
MBS8543655-01	Aldolase Rabbit pAb
59640	Aldolase Rabbit mAb
E47R2406	Aldolase A Rabbit pAb
JAA02452-01	Aldolase from rabbit muscle
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