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NF-E4 (Acetyl Lys43) rabbit pAb

CAT: 0855-ES1124-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES1124-01Size:50 µL
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Background
The erythroid-specific protein encoded by this gene, and the ubiquitous transcription factor CP2, form the stage selector protein (SSP) complex, which is involved in preferential expression of the gamma-globin genes in fetal erythroid cells. Alternate use of an in-frame upstream non-AUG (CUG) translation initiation codon, and a downstream AUG codon, results in two isoforms. While the long isoform (22 kDa) acts as an activator, the short isoform (14 kDa) has been shown to repress gamma-globin gene expression. This gene is located in an intron of the FBXL13 gene on the opposite strand. [provided by RefSeq, Jul 2008]
Description
The erythroid-specific protein encoded by this gene, and the ubiquitous transcription factor CP2, form the stage selector protein (SSP) complex, which is involved in preferential expression of the gamma-globin genes in fetal erythroid cells. Alternate use of an in-frame upstream non-AUG (CUG) translation initiation codon, and a downstream AUG codon, results in two isoforms. While the long isoform (22 kDa) acts as an activator, the short isoform (14 kDa) has been shown to repress gamma-globin gene expression. This gene is located in an intron of the FBXL13 gene on the opposite strand. [provided by RefSeq, Jul 2008],
Product Name Alternative
NFE4; Transcription factor NF-E4
UniProt
Q86UQ8
Swiss Prot
Q86UQ8
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized acetyl-peptide derived from the human NF-E4 around the acetylation site of K43.
Target
NF-E4
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000
Buffer
-20°C/1 year
Molecular Weight
19kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
19kD
Fragment
IgG
Subcellular Location
Nucleus .
Other Product Names
NFE4; Transcription factor NF-E4
Gene ID (Human)
58160

UniProtKB · Q86UQ8

Transcription factor NF-E4

NFE4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q86UQ8
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
NFE4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
—
Protein keywords

PTM

AcetylationUbl conjugation

Molecular function

ActivatorRepressor

Coding sequence diversity

Alternative initiation

Technical term

Direct protein sequencingReference proteome

Cellular component

Nucleus

Biological process

TranscriptionTranscription regulation

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