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Cleaved-Caspase-7 (S199) rabbit pAb

CAT: 0855-ES1006-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES1006-01Size:50 µL
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Background
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Description
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012],
UniProt
P55210
Swiss Prot
P55210
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human Caspase 7. AA range:180-229
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Molecular Weight
20kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
20kD
Fragment
IgG
Subcellular Location
Cytoplasm.
Other Product Names
CASP7; MCH3; Caspase-7; CASP-7; Apoptotic protease Mch-3; CMH-1; ICE-like apoptotic protease 3; ICE-LAP3
Gene ID (Human)
840

UniProtKB · P55210

Caspase-7

CASP7_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P55210
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CASP7
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
CASP-7
EC number
3.4.22.60
Processing
Precursor
Secondary accessions
B4DQU7, B5BU45, D3DRB8, Q13364, Q53YD5, Q5SVL0, Q5SVL3, Q96BA0
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoproteinUbl conjugationZymogen

Molecular function

Allosteric enzymeHydrolaseProteaseRNA-bindingThiol protease

Coding sequence diversity

Alternative splicing

Biological process

Apoptosis

Cellular component

CytoplasmNucleusSecreted

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Alternative Products

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E28PC0010Cleaved-Caspase-7 (S199) Rabbit Polyclonal Antibody
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