Cyamemazine

• Description :

  Cyamemazine is a neuroleptic agent that contains the phenothiazine chromophore. Cyamemazine is often used as an anxiolytic. Cyamemazine is a potent 5-HT3 (Ki of 12 nM), 5-HT2A (Ki = 1.5 nM) and 5-HT2C (Ki of 75 nM) receptors antagonist with antipsychotic activity[1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H410

• Target :

  5-HT Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/cyamemazine.html

• Purity :

  99.42

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CN(C)CC(C)CN1C2=C(C=CC(C#N)=C2)SC3=CC=CC=C31

• Molecular Formula :

  C19H21N3S

• Molecular Weight :

  323.46

• Precautions :

  H410

• References & Citations :

  [1]Bourin M, et al. Preclinical and clinical pharmacology of cyamemazine: anxiolytic effects and prevention of alcohol and benzodiazepine withdrawal syndrome. CNS Drug Rev. 2004 Fall;10 (3) :219-29.|[2] Vendrell-Criado V, et al. Photobehavior of the antipsychotic drug cyamemazine in a supramolecular gel protective environment. J Photochem Photobiol B. 2020 Jan;202:111686.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  5-HT2 Receptor; lactoferrin; α-1 microglobulin

• CAS Number :

  [3546-03-0]