Cytokeratin 18 Rabbit pAb

• Background:

  Keratin 18 is a type I cytokeratin. It is, together with its filament partner keratin 8, perhaps the most commonly found products of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.Keratin 18 is often used together with keratin 8 and keratin 19 to differentiate cells of epithelial origin from hematopoietic cells in tests that enumerate circulating tumor cells in blood.

• Description:

  Keratin 18 is a type I cytokeratin. It is, together with its filament partner keratin 8, perhaps the most commonly found products of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. Keratin 18 is often used together with keratin 8 and keratin 19 to differentiate cells of epithelial origin from hematopoietic cells in tests that enumerate circulating tumor cells in blood.

• Synonyms:

  Cell proliferation inducing gene 46 protein, CK 18, CYK 18, K 18, Keratin 18, Ketatin D, KRT18

• Gene ID:

  3875

• UniProt:

  P05783

• Cellular Locus:

  Cytoplasm, Intermediate filament, Keratin, Nucleus

• Host:

  Rabbit

• Species Reactivity:

  Human, Rat, Mouse

• Reactivity:

  Human, Rat, Mouse

• Immunogen:

  Recombinant Protein

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Source:

  Rabbit

• Applications:

  WB, IHC

• Validated Applications:

  WB, IHC

• Stability:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:1,000-2,000 IHC 1:500-1,000

• Molecular Weight:

  46kDa

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

• Observed Molecular Weight:

  46 kDa

• Subcellular Location:

  Cytoplasm, Intermediate filament, Keratin, Nucleus

• Other Product Names:

  Cell proliferation inducing gene 46 protein, CK 18, CYK 18, K 18, Keratin 18, Ketatin D, KRT18

• Gene ID (Human):

  3875

• SwissProt (Human):

  P05783