Lamin B1 Rabbit pAb

• Background:

  The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1.

• Description:

  The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1.

• Synonyms:

  ADLD, LMB1, LMNB1, MGC111419, OTTHUMP00000159218

• Gene ID:

  4001

• UniProt:

  P20700

• Cellular Locus:

  Mitochondrion inner membrane

• Host:

  Rabbit

• Species Reactivity:

  Human, Rat, Mouse

• Reactivity:

  Human, Rat, Mouse

• Immunogen:

  Recombinant Protein

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Source:

  Rabbit

• Applications:

  WB, IHC

• Validated Applications:

  WB, IHC

• Stability:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:1,000-3,000 IHC: 1:500-1,000

• Molecular Weight:

  68,45kDa

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

• Observed Molecular Weight:

  68,45 kDa

• Subcellular Location:

  Mitochondrion inner membrane

• Other Product Names:

  ADLD, LMB1, LMNB1, MGC111419, OTTHUMP00000159218

• Gene ID (Human):

  4001

• SwissProt (Human):

  P20700