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Collagen I (4B5) Mouse mAb

CAT: 0855-EM1387-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-EM1387-01Size:50 µL
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Background
Type 1 collagen is a trimeric complex comprised of two molecules of COL1A1 (alpha-1 type 1 collagen) and one molecule of COL1A2 (alpha-2 type 1 collagen) . The expression levels of COL1A1 are regulated by multiple mechanisms, including mRNA stability, translation, and posttranslational modification.
Description
Type 1 collagen is a trimeric complex comprised of two molecules of COL1A1 (alpha-1 type 1 collagen) and one molecule of COL1A2 (alpha-2 type 1 collagen). The expression levels of COL1A1 are regulated by multiple mechanisms, including mRNA stability, translation, and posttranslational modification.
Product Name Alternative
Alpha 1 type I collagen, COL1A1, COL1A3
UniProt
P02452
Swiss Prot
P02452
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic Peptide
Clonality
Monoclonal
Source
Mouse
Applications
IHC
Concentration
1mg/mL
Dilution
IHC 1:100-200
Buffer
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Molecular Weight
139kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
139kDa
Fragment
IgG1
Subcellular Location
Secreted, extracellular space, extracellular matrix
Other Product Names
Alpha 1 type I collagen, COL1A1, COL1A3
Gene ID (Human)
1277/1278

UniProtKB · P02452

Collagen alpha-1(I) chain

CO1A1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P02452
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
COL1A1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
O76045, P78441, Q13896, Q13902, Q13903, Q14037, Q14992, Q15176, Q15201, Q16050, Q59F64, Q7KZ30, Q7KZ34, Q8IVI5, Q8N473, Q9UML6, Q9UMM7
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Ligand

CalciumMetal-binding

Coding sequence diversity

Chromosomal rearrangement

Domain

CollagenRepeatSignal

Disease

Disease variantDwarfismEhlers-Danlos syndromeOsteogenesis imperfectaOsteoporosis

PTM

Disulfide bondGlycoproteinHydroxylationPhosphoproteinPyrrolidone carboxylic acid

Cellular component

Extracellular matrixSecreted

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