Alkannin

• Description :

  Alkannin is a potent and specific inhibitor of tumor-specific pyruvate kinase-M2 (PKM2) . Alkannin does not inhibit PKM1 and pyruvate kinase-L (PKL) . Alkannin acts as a potential anticancer agent[1].

• UNSPSC :

  12352005

• Target :

  Pyruvate Kinase

• Type :

  Natural Products

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/alkannin-1.html

• Solubility :

  10 mM in DMSO

• Smiles :

  OC1=C(C=C(C2=C1C(C=CC2=O)=O)O)[C@H](C/C=C(C)\C)O

• Molecular Formula :

  C16H16O5

• Molecular Weight :

  288.30

• References & Citations :

  [1]J Chen, et al. Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2. Oncogene. 2011 Oct 20;30 (42) :4297-306.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [23444-65-7]