Angoline

• UNSPSC Description:

  Angoline is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation[1].

• Target Antigen:

  Interleukin Related; STAT

• Type:

  Natural Products

• Related Pathways:

  Immunology/Inflammation;JAK/STAT Signaling;Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/angoline.html

• Purity:

  99.67

• Solubility:

  DMSO : 20.83 mg/mL (ultrasonic)

• Smiles:

  CN1C2=C3C(C=C4OCOC4=C3)=CC=C2C5=C(C(OC)=C(OC)C=C5)C1OC

• Molecular Weight:

  379.41

• References & Citations:

  [1]Jiawei Liu, et al. Angoline: a selective IL-6/STAT3 signaling pathway inhibitor isolated from Zanthoxylum nitidum. Phytomedicine. Jul-Aug 2014;21(8-9):1088-91.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Clinical Information:

  No Development Reported

• CAS Number:

  21080-31-9