Angoline

• Description :

  Angoline is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H301, H335

• Target :

  Interleukin Related; STAT

• Type :

  Natural Products

• Related Pathways :

  Immunology/Inflammation; JAK/STAT Signaling; Stem Cell/Wnt

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/angoline.html

• Purity :

  99.67

• Solubility :

  DMSO : 20.83 mg/mL (ultrasonic)

• Smiles :

  CN1C2=C3C(C=C4OCOC4=C3)=CC=C2C5=C(C(OC)=C(OC)C=C5)C1OC

• Molecular Formula :

  C22H21NO5

• Molecular Weight :

  379.41

• Precautions :

  H301, H335

• References & Citations :

  [1]Jiawei Liu, et al. Angoline: a selective IL-6/STAT3 signaling pathway inhibitor isolated from Zanthoxylum nitidum. Phytomedicine. Jul-Aug 2014;21 (8-9) :1088-91.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [21080-31-9]