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Recombinant Murine Midkine

CAT: 0355-AP60208Size: InquireDry Ice: NoHazardous: No
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CAT#:0355-AP60208Size:Inquire
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Background
Midkine, also named MK, MK1, NEGF 2, is belonging to the neurotrophic and developmentally-regulated heparin-binding molecules family. It is encoded by the MDK gene. The Midkine protein includes five intrachain disulfide bonds which hold two domains and there are three antiparallel beta-sheets in each domain. A chondroitin sulfate proteoglycan, protein-tyrosine phosphatase zeta (PTPzeta), is a receptor for MK. MK promotes the growth, survival, and migration of various cells, and plays roles in neurogenesis and epithelial mesenchymal interactions during organogenesis. The predicted molecular weight is approximately 13.3 kDa, based on a mature peptide length of 118 amino acid residues in the mouse and 121 amino acid residues in the human. Across species, MK shows 87 % identity between the human and murine proteins.
Product Name Alternative
Retinoic Acid-induced Differentiation Factor
Gene ID
17242
UniProt
P12025
Target
VAKKKEKVKK GSECSEWTWG PCTPSSKDCG MGFREGTCGA QTQRVHCKVP CNWKKEFGAD CKYKFESWGA CDGSTGTKAR QGTLKKARYN AQCQETIRVT KPCTSKTKSK TKAKKGKGKD
Purification
> 96 % by SDS-PAGE and HPLC analyses.
Endotoxin
Less than 1 EU/ug of rMuMidkine as determined by LAL method.
Bioactivity
Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human neutrophils is in a concentration range of 10-100 ng/ml.
Storage Conditions
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.- 12 months from date of receipt, -20 to -70 °C as supplied.- 1 month, 2 to 8 °C under sterile conditions after reconstitution.- 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Calculated Molecular Weight
Approximately 13.2 kDa, a single non-glycosylated polypeptide chain containing 120 amino acids.
Formulation
Lyophilized from a 0.2 μm filtered concentrated solution in 2 x PBS, pH7.4.
Host or Source
Escherichia coli

UniProtKB · P12025

Midkine

MK_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
P12025
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Mdk
Protein existence
1: Evidence at protein level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
MK
EC number
—
Processing
Precursor
Secondary accessions
—
Protein keywords

Molecular function

Developmental proteinGrowth factorHeparin-bindingMitogen

Biological process

Differentiation

PTM

Disulfide bond

Technical term

Reference proteome

Cellular component

Secreted

Domain

Signal

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