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Golgicide A

CAT: 0026-B3070-5Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0026-B3070-5Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ADP-ribosylation factor 1 (Arf1) plays an important role in regulating secretory traffic and membrane transport within the Golgi. Arf1 is activated by guanine nucleotide exchange factors (ArfGEFs). Golgicide A is a potent, specific and reversible inhibitor of the cis-Golgi ArfGEF GBF1. Inhibition of GBF1 function results in rapid dissociation of COPI vesicle coat from Golgi membranes and subsequent disassembly of the Golgi and trans-Golgi network (TGN). Golgicide A inhibits the effect of shiga toxin on protein synthesis with an IC₅₀ of 3.3 μM in Vero cells.
Shipping Conditions
RT
Storage Conditions
-20ºC
Shelf Life
36 months

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