BX-320

CAT: 0026-B2916-5Size: 5 mgDry Ice: NoHazardous: No
CAT#:0026-B2916-5Size:5 mg
Selected
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BX-320 is an inhibitor of 3-phosphoinositide-dependent kinase-1 (PDK1). The phosphoinositide 3-kinase/PDK1/Akt signaling pathway plays an important role in cancer cell growth, survival and angiogenesis. BX-320 inhibits PDK1 enzyme activity in a kinase assay with an IC₅₀ of 30 nM. BX-320 blocks the growth of MDA-453, U87-MG and PC-3 cells in soft agar with IC₅₀ values of 0.093 μM, 0.3 μM and 0.4 μM respectively. BX-320 inhibits the growth of LOX melanoma tumors in mice models.
Shipping Conditions
Gel Pack
Storage Conditions
-20ºC
Shelf Life
36 months

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