BX-320

• Description:

  BX-320 is an inhibitor of 3-phosphoinositide-dependent kinase-1 (PDK1). The phosphoinositide 3-kinase/PDK1/Akt signaling pathway plays an important role in cancer cell growth, survival and angiogenesis. BX-320 inhibits PDK1 enzyme activity in a kinase assay with an IC₅₀ of 30 nM. BX-320 blocks the growth of MDA-453, U87-MG and PC-3 cells in soft agar with IC₅₀ values of 0.093 μM, 0.3 μM and 0.4 μM respectively. BX-320 inhibits the growth of LOX melanoma tumors in mice models.

• Shipping Conditions:

  Gel Pack

• Storage Conditions:

  -20ºC

• Shelf Life:

  36 months