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Cdk9 Inhibitor II

CAT: 0026-B2903-1Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0026-B2903-1Size:1 mg
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Description
Cdk9 Inhibitor II is a potent and selective inhibitor of Cdk9 with an IC₅₀ value of 0.35 µM in vitro. It is also an inhibitor of Cdk2-cyclin E with respect to ATP, with Ki and IC₅₀ values of 13.3 µM and 20 µM respectively. It reduces the frequency of S-phase cells in the cancer cell line HT-29 and decreases the phosphorylation of the retinoblastoma protein and the C-terminal domain of RNA polymerase II. It inhibits mRNA synthesis and induces the tumor suppressor protein p53. It inhibits cell proliferation of cancer cell lines such as MCF-7, HOS, G361, and K562 cells with IC₅₀ values of 33 µM, 49 µM, 64 µM, and 62 µM respectively.
Shipping Conditions
RT
Storage Conditions
-20ºC
Shelf Life
36months

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