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Aurkin A

CAT: 0804-HY-125956-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-125956-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Aurkin A is an allosteric inhibitor for the interaction between Aurora A Kinase (also known also Aurka) and TPX2, through targeting the TPX2 binding sites with Kd of 3.77 μM. Aurkin A can disrupt polyploidy induced by Alisertib and increase apoptosis of tumor cells. Aurkin A can be used in research on mitosis and cancer[1][2].
CAS Number
1534060-58-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Apoptosis; Aurora Kinase
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/aurkin-a.html
Purity
98.0
Smiles
O=C(C1=C2C=CC=C(F)C2=NC(C3=CC(Br)=CC=C3)=C1)O
Molecular Formula
C16H9BrFNO2
Molecular Weight
346.15
Precautions
H302, H315, H319
References & Citations
[1]Janeček M, et al., Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2. Sci Rep. 2016 Jun 24;6:28528. |[2]Conway PJ, et al. Aurkin-A, a TPX2-Aurora A small molecule inhibitor disrupts Alisertib-induced polyploidy in aggressive diffuse large B cell lymphoma. Neoplasia. 2024 Sep;55:101014.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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