4EGI-1

CAT: 0026-B2901-1Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0026-B2901-1Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

4EGI-1 is an inhibitor of the interaction of translation initiation factor eIF4G to eIF4E. It inhibits the binding of eIF4G to eIF4E, but not 4E-BP1. The KD for eIF4E binding to 4EGI-1 is 25 μM ± 11 μM. It inhibits proliferation of human cancer cells. It reduces the expression of c-Myc, Cyclin D1, Cyclin E, Bcl-2, bFGF and Survivin in human melanoma cells at a concentration of 50 μM. It strongly inhibits tumor growth in xenograft models of human breast and melanoma cancers.

Shipping Conditions

Storage Conditions

-20ºC

Shelf Life

36 months

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BE177467-01	4EGI-1

4EGI-1

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