RTA 408

• Description:

  RTA 408 is a synthetic oleanane triterpenoid that activates Nrf2. RTA 408 activates Nrf2 and suppresses nitric oxide and pro-inflammatory cytokine levels in interferon-γ-stimulated RAW 264.7 macrophage cells at low concentrations (≤ 25 nM). It inhibits growth of tumor cells with a GI₅₀ value of 260 ± 74 nM. Topical application of RTA 408 induces cytoprotective genes and protects mice from radiation-induced dermatitis.

• Shipping Conditions:

  RT

• Storage Conditions:

  -20ºC

• Shelf Life:

  36 months