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MS37452

CAT: 0026-B2851-5Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0026-B2851-5Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MS37452 is a competitive inhibitor of CBX7 (Chromobox homolog 7) chromodomain binding to trimethylated lysine 27 of histone 3 (H3K27me3). It inhibits CBX7-H3K27me3 binding with a Ki of 43.0 μM. At 250 µM, it derepresses transcription of Polycomb repressive complex target gene p16/CDKN2A by displacing CBX7 binding to the INK4A/ARF locus in PC3 prostate cancer cells.
Shipping Conditions
RT
Storage Conditions
-20ºC
Shelf Life
36 months

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