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PP121

CAT: 0026-B2523-25Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0026-B2523-25Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PP121 is a dual inhibitor of tyrosine and phosphoinositide kinases. PP121 inhibits both tyrosine kinases and PI3-Ks but not serine-threonine kinases. It potently inhibits p110α, p110β, p110γ, p110δ, DNA-PK and mTOR with IC50 values of 52nM, 1.4μM, 1.1μM, 150nM, 60nM and 10nM, respectively. For the tyrosine kinases, PP121 displays inhibition with IC50 values of 21nM, 4nM, 10nM,55nM, 550nM, 220nM and <1nM for Ab1, Hck, Src, VEGFR2, EGFR, EphB4 and PDGFR, respectively.
Shipping Conditions
Gel Pack
Storage Conditions
-20ºC
Shelf Life
36 months

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