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BX795

CAT: 0804-HY-10514-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10514-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BX795 is a potent and selective inhibitor of PDK1, with an IC50 of 6 nM. BX795 is also a potent and relatively specific inhibitor of TBK1 and IKKε, with an IC50 of 6 and 41 nM, respectively. BX795 blocks phosphorylation of S6K1, Akt, PKCδ, and GSK3β, and has lower selectivity over PKA, PKC, c-Kit, GSK3β etc. BX795 modulates autophagy[1][2][3][4].
CAS Number
702675-74-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; IKK; PDK-1
Type
Reference compound
Related Pathways
Autophagy; NF-κB; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/BX795.html
Purity
99.84
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
O=C(NCCCNC1=C(C=NC(NC2=CC=CC(NC(N3CCCC3)=O)=C2)=N1)I)C4=CC=CS4
Molecular Formula
C23H26IN7O2S
Molecular Weight
591.47
Precautions
H302, H315, H319, H335
References & Citations
[1]Feldman RI, et al. Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1. J Biol Chem. 2005 May 20;280 (20) :19867-74.|[2]Clark K, et al. Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and activation. J Biol Chem. 2009 May 22;284 (21) :141|[3]Dangelmaier C, et al. PDK1 selectively phosphorylates Thr (308) on Akt and contributes to human platelet functional responses. Thromb Haemost. 2014 Mar 3;111 (3) :508-17.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IKKε; TBK1

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CatalogName
A8222-SBX795

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