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HS-1371

CAT: 0026-B2430-25Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0026-B2430-25Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HS-1371 is a potent RIP3 kinase inhibitor (IC₅₀ = 20.8 nM). It binds to the ATP binding pocket of RIP3 and inhibits ATP binding to prevent RIP3 enzymatic activity in vitro. . It inhibits TNF-induced necroptosis but does not inhibit TNF-induced apoptosis, indicating that HS-1371 has a specific inhibitory effect on RIP3-mediated necroptosis via the suppression of RIP3 kinase activity.
Shipping Conditions
Gel Pack
Storage Conditions
-20ºC
Shelf Life
36 months

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