TCV-309 (chloride)

CAT: 0804-HY-19121A-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-19121A-01Size:5 mg

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Description

TCV-309 chloride is a potent and specific platelet activating factor (PAF) antagonist. TCV-309 chloride specifically inhibits PAF-induced aggregation of rabbit and human platelets, and [3H]PAF binding to rabbit platelet microsomes with IC50 values of 33 nM, 58 nM and 27 nM, respectively. TCV-309 chloride has beneficial effects in anaphylactic shock[1][2].

CAS Number

121494-09-5

UNSPSC

12352005

Target

Platelet-activating Factor Receptor (PAFR)

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/TCV-309-chloride.html

Concentration

10mM

Purity

95.0

Solubility

DMSO : 6.3 mg/mL (ultrasonic)

Smiles

CCC[N+]1=CC(C(N(CCC(NCCOC(N2CC3=C(C=CC=C3)CC2)=O)=O)C4=CC=CC=C4)=O)=CC(Br)=C1.[Cl-]

Molecular Formula

C30H34BrClN4O4

Molecular Weight

629.97

References & Citations

[1]Terashita Z et al. Beneficial effects of TCV-309, a novel potent and selective platelet activating factor antagonist in endotoxin and anaphylactic shock in rodents. J Pharmacol Exp Ther. 1992 Feb;260 (2) :748-55.|[2]M Poeze, et al. Decreased organ failure in patients with severe SIRS and septic shock treated with the platelet-activating factor antagonist TCV-309: a prospective, multicenter, double-blind, randomized phase II trial. TCV-309 Septic Shock Study Group. Shock. 2000 Oct;14 (4) :421-8.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Chemical Information

TCV-309 chloride

CAS Number	121494-09-5
PubChem CID	15037614
IUPAC Name	2-[3-(N-(5-bromo-1-propylpyridin-1-ium-3-carbonyl)anilino)propanoylamino]ethyl 3,4-dihydro-1H-isoquinoline-2-carboxylate chloride
Molecular Formula	C30H34BrClN4O4
Molecular Weight	630.0
Topological Polar Surface Area	82.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	11
Heavy Atom Count	40
Formal Charge	0
Complexity	808

SMILES

CCC[N+]1=CC(=CC(=C1)Br)C(=O)N(CCC(=O)NCCOC(=O)N2CCC3=CC=CC=C3C2)C4=CC=CC=C4.[Cl-]

InChI

InChI=1S/C30H33BrN4O4.ClH/c1-2-15-33-20-25(19-26(31)22-33)29(37)35(27-10-4-3-5-11-27)17-13-28(36)32-14-18-39-30(38)34-16-12-23-8-6-7-9-24(23)21-34;/h3-11,19-20,22H,2,12-18,21H2,1H3;1H

InChIKey

HBWMSZWQSYEBPL-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 121494-09-5

CID: 15037614

Formula: C30H34BrClN4O4

MW: 630.0

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	630.0
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	11
Exact Mass	628.14520
Monoisotopic Mass	628.14520
Topological Polar Surface Area	82.8 Å²
Heavy Atom Count	40
Formal Charge	0
Complexity	808
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	2
Compound Is Canonicalized	Yes

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HY-P4961	Tau Peptide (295-309)
HY-P70463-01	I-309/CCL1, Human
HY-P7199	I-309/CCL1, Human
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Alternative Products

Catalog	Name
GTR19204668-01	TCV-309 chloride
GTR19196354-01	TCV-309
TRC-T012750-100MG	TCV 295
RC315-12	I-309, I-309 (rHuI-309, CCL1), human
3895/10	NS 309
GTR19194160	K 309
407417	eCF-309
T16902-01	SMND-309
GTR18904234-01	I-309
B1300-25	PQR-309

TCV-309 (chloride)

Chemical Information

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