2-Hydroxybenzimidazole

• Description:

  2-Hydroxybenzimidazole is an inactive compound targeting CYP1A1 and is mainly used as a control compound in the structure-activity relationship study of benzimidazole derivatives. 2-Hydroxybenzimidazole does not have the ability to induce CYP1A1 expression like its thiol or amino substituted derivatives[1].

• UNSPSC:

  12352200

• Hazard Statement:

  H302

• Target:

  Cytochrome P450

• Type:

  Biochemical Assay Reagents

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/2-hydroxybenzimidazole.html

• Purity:

  99.98

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O=C1NC2=CC=CC=C2N1

• Molecular Formula:

  C7H6N2O

• Molecular Weight:

  134.14

• Precautions:

  H302

• References & Citations:

  [1]Backlund M, et al. Structural and mechanistic aspects of transcriptional induction of cytochrome P450 1A1 by benzimidazole derivatives in rat hepatoma H4IIE cells. Eur J Biochem. 1999 Apr;261 (1) :66-71.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Biochemical Assay Reagents

• Clinical Information:

  No Development Reported

• Isoform:

  CYP1

• CAS Number:

  [615-16-7]