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NSC 194308

CAT: 0804-HY-153736-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-153736-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NSC 194308, a U2AF2-RNA complexes enhancer, increases association of the U2AF1-U2AF2-SF1-splice site RNA complex by binding a site between the U2AF2 RNA recognition motifs (RRM1 and RRM2) . NSC 194308 inhibits pre-mRNA splicing by stalling spliceosome assembly at the point where U2AF helps recruit U2 snRNP to the branchpoint. NSC 194308 enhances the binding of pre-mRNA to U2AF2, selectively triggering cell death in leukemia cell lines containing spliceosome mutations[1].
CAS Number
90379-42-3
UNSPSC
12352211
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nsc-194308.html
Purity
98.40
Solubility
DMSO : ≥ 50 mg/mL
Smiles
N=C(CS[S](=O)(O)=O)NC[C@@H]1C(CC2CC1)C2(C)C
Molecular Formula
C12H22N2O3S2
Molecular Weight
306.44
References & Citations
[1]Rakesh Chatrikhi, et al. A synthetic small molecule stalls pre-mRNA splicing by promoting an early-stage U2AF2-RNA complex. Cell Chem Biol. 2021 Aug 19;28 (8) :1145-1157.e6.|[2]Riccardo Rozza, et al. Assessing the Binding Mode of a Splicing Modulator Stimulating Pre-mRNA Binding to the Plastic U2AF2 Splicing Factor. J Chem Inf Model. 2023 Dec 11;63 (23) :7508-7517.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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