(-) -Gallocatechin

• Description:

  (-) -Gallocatechin, an epimer of (-) -Epigallocatechin (EGC), is contained in various tea products. (-) -Gallocatechin has antioxidant activities. (-) -Gallocatechin is the main active component in green tea extract (HTP-GTE) responsible for its effect of improving age-related cognitive impairments involving protein kinase A (PKA) pathway[1][2][3][4].

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H335

• Target:

  Drug Isomer; Reactive Oxygen Species (ROS)

• Type:

  Natural Products

• Related Pathways:

  Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Cancer; Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/minus-gallocatechin.html

• Purity:

  99.98

• Solubility:

  DMSO : 100 mg/mL (ultrasonic) |H2O : 1.67 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O[C@H]1[C@H](C2=CC(O)=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C3C1

• Molecular Formula:

  C15H14O7

• Molecular Weight:

  306.27

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]Takagaki A, et, al. Biotransformation of (-) -epigallocatechin and (-) -gallocatechin by intestinal bacteria involved in isoflavone metabolism. Biol Pharm Bull. 2015;38 (2) :325-30.|[2]Xu JZ, et, al. Comparison of antioxidant activity and bioavailability of tea epicatechins with their epimers. Br J Nutr. 2004 Jun;91 (6) :873-81.|[3]Ikeda I, et, al. Heat-epimerized tea catechins rich in gallocatechin gallate and catechin gallate are more effective to inhibit cholesterol absorption than tea catechins rich in epigallocatechin gallate and epicatechin gallate. J Agric Food Chem. 2003 Dec 3;51 (25) :7303-7.|[4]Ahn JW, Kim S, Ko S, Kim YH, Jeong JH, Chung S. Modified (-) -gallocatechin gallate-enriched green tea extract rescues age-related cognitive deficits by restoring hippocampal synaptic plasticity. Biochem Biophys Rep. 2022;29:101201.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  3371-27-5