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Iberin

CAT: 0804-HY-101413-01Size: 1 mg (61.25 mM x 100 μL in Ethanol)Dry Ice: NoHazardous: No
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CAT#:0804-HY-101413-01Size:1 mg (61.25 mM x 100 μL in Ethanol)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Iberin (NSC 321801), a sulfoxide analogue of sulforaphane, is a naturally occurring member of isothiocyanate family. Iberin inhibits cell survival with an IC50 of 2.3 μM in HL60 cell. Iberin induces apoptosis.
CAS Number
505-44-2
Product Name Alternative
NSC 321801
UNSPSC
12352211
Hazard Statement
H301+H311+H331, H315, H319, H335, H410
Target
Apoptosis; Bacterial; Endogenous Metabolite
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Iberin.html
Concentration
61.25 mM * 1 mL in Ethanol
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=S(CCCN=C=S)C
Molecular Formula
C5H9NOS2
Molecular Weight
163.26
Precautions
H301+H311+H331, H315, H319, H335, H410
References & Citations
[1]Jakubikova J, et al. Isothiocyanates induce cell cycle arrest, apoptosis and mitochondrial potential depolarization in HL-60 and multidrug-resistant cell lines. Anticancer Res. 2005 Sep-Oct;25 (5) :3375-86.|[2]Jadhav U, et al. Iberin induces cell cycle arrest and apoptosis in human neuroblastoma cells.|[3]Jadhav U, et al. Dietary isothiocyanate iberin inhibits growth and induces apoptosis in human glioblastoma cells. J Pharmacol Sci. 2007 Feb;103 (2) :247-51.|[4]Jakobsen TH, et al. Food as a source for quorum sensing inhibitors: iberin from horseradish revealed as a quorumsensing inhibitor of Pseudomonas aeruginosa. Appl Environ Microbiol. 2012 Apr;78 (7) :2410-21.|[5]Munday R, et al. Induction of phase II detoxification enzymes in rats by plant-derived isothiocyanates: comparison of allyl isothiocyanate with sulforaphane and related compounds. J Agric Food Chem. 2004 Apr 7;52 (7) :1867-71.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Natural Products
Clinical Information
No Development Reported

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