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GW297361

CAT: 0804-HY-153556-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-153556-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GW297361 is an oxindole CDK inhibitor that elicits a Pho85-selective response in cells. GW297361 inhibits yeast Cdk1 and Pho85 with IC50s of 20 nM and 400 nM in vitro, respectively[1].
CAS Number
388627-21-2
UNSPSC
12352005
Target
CDK; Src; VEGFR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/gw297361.html
Purity
98.13
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=S(C1=CC=C(N/C=C(C2=C(SC=N3)C3=CC=C2N4)\C4=O)C=C1)(N)=O
Molecular Formula
C16H12N4O3S2
Molecular Weight
372.42
References & Citations
[1]Kung C, et al. Selective kinase inhibition by exploiting differential pathway sensitivity. Chem Biol. 2006 Apr;13 (4) :399-407.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK1; CDK2; CDK4; CDK9; Pho85; VEGFR2/KDR/Flk-1

Chemical Information

4-[[(Z)-(7-oxo-6H-pyrrolo[2,3-g][1,3]benzothiazol-8-ylidene)methyl]amino]benzenesulfonamide
CAS Number388627-21-2
PubChem CID135421144
IUPAC Name4-[(7-hydroxy-6H-pyrrolo[2,3-g][1,3]benzothiazol-8-yl)methylideneamino]benzenesulfonamide
Molecular FormulaC16H12N4O3S2
Molecular Weight372.4
XLogP2.3
Topological Polar Surface Area158
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Heavy Atom Count25
Formal Charge0
Complexity615
SMILES
C1=CC(=CC=C1N=CC2=C(NC3=C2C4=C(C=C3)N=CS4)O)S(=O)(=O)N
InChI
InChI=1S/C16H12N4O3S2/c17-25(22,23)10-3-1-9(2-4-10)18-7-11-14-12(20-16(11)21)5-6-13-15(14)24-8-19-13/h1-8,20-21H,(H2,17,22,23)
InChIKey
OTEUBDUXVNFEFC-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4-[[(Z)-(7-oxo-6H-pyrrolo[2,3-g][1,3]benzothiazol-8-ylidene)methyl]amino]benzenesulfonamide
CAS: 388627-21-2
CID: 135421144
Formula: C16H12N4O3S2
MW: 372.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight372.4
XLogP32.3
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Exact Mass372.03508260
Monoisotopic Mass372.03508260
Topological Polar Surface Area158 Ų
Heavy Atom Count25
Formal Charge0
Complexity615
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
BA3817-1GW297361

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