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Homoharringtonine

CAT: 0607-N1504-20Size: 20 mgDry Ice: NoHazardous: No
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CAT#:0607-N1504-20Size:20 mg
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Description
Cytotoxic alkaloid
CAS Number
26833-87-4
Product Name Alternative
(R)-1-((11bS,12S,14aR)-13-methoxy-2,3,5,6,11b,12-hexahydro-1H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]cyclopenta[b]pyrrolo[1,2-a]azepin-12-yl) 4-methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)succinate
Field of Research
Natural Products
Purity
0.9854
Solubility
insoluble in H2O; ≥10.92 mg/mL in EtOH; ≥181.2 mg/mL in DMSO
Molecular Formula
C29H39NO9
Molecular Weight
545.62
Shipping Conditions
Blue ice
Storage Conditions
Store at -20°C.

Chemical Information

Omacetaxine Mepesuccinate

Omacetaxine mepesuccinate is a cephalotaxine-derived alkaloid ester obtained from Cephalotaxus harringtonia; used for the treatment of chronic or accelerated phase chronic myeloid leukaemia. It has a role as an anticoronaviral agent, an antineoplastic agent, a protein synthesis inhibitor and an apoptosis inducer. It is a tertiary alcohol, an organic heteropentacyclic compound, an alkaloid ester and an enol ether. It is functionally related to a cephalotaxine.

CAS Number26833-87-4
PubChem CID285033
IUPAC Name1-O-[(2S,3S,6R)-4-methoxy-16,18-dioxa-10-azapentacyclo[11.7.0.02,6.06,10.015,19]icosa-1(20),4,13,15(19)-tetraen-3-yl] 4-O-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate
Molecular FormulaC29H39NO9
Molecular Weight545.6
XLogP0.8
Topological Polar Surface Area124
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count10
Rotatable Bond Count11
Heavy Atom Count39
Formal Charge0
Complexity968
SMILES
CC(C)(CCC[C@@](CC(=O)OC)(C(=O)O[C@H]1[C@H]2C3=CC4=C(C=C3CCN5[C@@]2(CCC5)C=C1OC)OCO4)O)O
InChI
InChI=1S/C29H39NO9/c1-27(2,33)8-5-10-29(34,16-23(31)36-4)26(32)39-25-22(35-3)15-28-9-6-11-30(28)12-7-18-13-20-21(38-17-37-20)14-19(18)24(25)28/h13-15,24-25,33-34H,5-12,16-17H2,1-4H3/t24-,25-,28+,29-/m1/s1
InChIKey
HYFHYPWGAURHIV-JFIAXGOJSA-N
Chemical Structure
2D Structure
2D structure of Omacetaxine Mepesuccinate
CAS: 26833-87-4
CID: 285033
Formula: C29H39NO9
MW: 545.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight545.6
XLogP30.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count10
Rotatable Bond Count11
Exact Mass545.26248182
Monoisotopic Mass545.26248182
Topological Polar Surface Area124 Ų
Heavy Atom Count39
Formal Charge0
Complexity968
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
HY-14944-01Homoharringtonine

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