Recombinant anti-Human NKG2D mAb

Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Dry Ice Shipment: Yes

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CAT:

980-GMP-A075-01

Size:

50 µg

Price:

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For price, please contact [email protected].

Recombinant anti-Human NKG2D mAb

Description: NKG2D (Natural-killer group 2, member D) is also known as NK cell receptor D or CD314. Encoded by KLRK1 gene, NKG2D is a disulfide-bonded homodimer and can form a heterohexamer with four subunits of HCST/DAP10. NKG2D contains a cytoplasmic domain (aa 1-51), helical membrane-spanning domain (aa 52-72), and extracellular domain (aa 73-216). NKG2D is mainly expressed on the surface of NK, NKT, γ δ T, and CD8+ T cells. It acts as an activating receptor to mediate the activation of the above-mentioned immune cells for killing target cells. NKG2D is involved in immune surveillance as an activated and co-stimulatory receptor after binding to various cellular stress-induced ligands on the surface of autologous tumor cells and virus-infected cells. Also, it provides stimulated and co-stimulated innate immune responses on activated natural killer (NK) cells, resulting in their cytotoxic activity. Furthermore, through expanding T cell activation, NKG2D acts as a co-stimulatory receptor for T cell receptors (TCRs) in CD8+ T cell-mediated adaptive immune responses. Recombinant Anti-Human NKG2D mAb is expressed by mammalian cells, and is produced with raw materials of pharmaceutical applicable level. The host protein residue, nucleic acid residue and common pathogens are strictly controlled, and the production and quality management procedures of the product comply with GMP regulations to ensure the traceability of the production process and all raw materials.
Shipping Conditions: Dry Ice
Storage Conditions: -20°C
Shelf Life: 24 Months

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Cat	Name
GMP-A075-01	Recombinant anti-Human NKG2D mAb
GMP-A075-02	Recombinant anti-Human NKG2D mAb
GMP-A075-03	Recombinant anti-Human NKG2D mAb
NC008-02	Anti-Human NKG2D mAb
NC008-01	Anti-Human NKG2D mAb
CP46-01	Recombinant Human NKG2D (N-6His)
CP46-02	Recombinant Human NKG2D (N-6His)
CU41-02	Recombinant Human NKG2D (N-Fc)
CU41-01	Recombinant Human NKG2D (N-Fc)
CP46-04	Recombinant Human NKG2D (N-6His)