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7-Chlorokynurenic acid

CAT: 0607-B6232-50Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0607-B6232-50Size:50 mg
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Description
NMDA receptor glycine site antagonist
CAS Number
18000-24-3
Product Name Alternative
7-chloro-4-oxo-1,4-dihydroquinoline-2-carboxylic acid
Field of Research
Membrane Transporter Ion Channel Glutamate (EAAT) Transporters
Purity
0.98
Form
White solid
Solubility
Soluble in DMSO
Smiles
ClC1=CC=C2C(NC(C(O)=O)=CC2=O)=C1
Molecular Formula
C10H6ClNO3
Molecular Weight
223.62
Shipping Conditions
Blue ice
Storage Conditions
Store at RT.

Chemical Information

7-Chlorokynurenic acid

7-chlorokynurenic acid is a quinolinemonocarboxylic acid that is quinaldic acid which is substituted by a hydroxy group at position 4 and by a chlorine at position 7. It is a potent NMDA glutamate receptor antagonist which antagonizes the strychnine-insensitive glycine site of the NMDA receptor. It also prevents neurodegeneration produced by quinolinic acid. It has a role as a NMDA receptor antagonist and a neuroprotective agent. It is a quinolinemonocarboxylic acid and an organochlorine compound.

CAS Number18000-24-3
PubChem CID1884
IUPAC Name7-chloro-4-oxo-1H-quinoline-2-carboxylic acid
Molecular FormulaC10H6ClNO3
Molecular Weight223.61
XLogP1.9
Topological Polar Surface Area66.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Heavy Atom Count15
Formal Charge0
Complexity340
SMILES
C1=CC2=C(C=C1Cl)NC(=CC2=O)C(=O)O
InChI
InChI=1S/C10H6ClNO3/c11-5-1-2-6-7(3-5)12-8(10(14)15)4-9(6)13/h1-4H,(H,12,13)(H,14,15)
InChIKey
UAWVRVFHMOSAPU-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 7-Chlorokynurenic acid
CAS: 18000-24-3
CID: 1884
Formula: C10H6ClNO3
MW: 223.61
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight223.61
XLogP31.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Exact Mass223.0036207
Monoisotopic Mass223.0036207
Topological Polar Surface Area66.4 Ų
Heavy Atom Count15
Formal Charge0
Complexity340
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
254446-017-Chlorokynurenic acid
HY-100811R-017-Chlorokynurenic acid (Standard)
3697/507-Chlorokynurenic acid sodium salt
HY-100811A-017-Chlorokynurenic acid (sodium salt)

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