Products for Research Use Only
RegisterLogin

AZD8835

CAT: 0607-B6178-5Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0607-B6178-5Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
PI3Kα and PI3Kδ inhibitor
CAS Number
1620576-64-8
Product Name Alternative
1-(4-(5-(5-amino-6-(5-(tert-butyl)-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1H-1,2,4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one
Field of Research
PI3K Akt mTOR Signaling PI3K
Purity
0.98
Solubility
Soluble in DMSO
Smiles
O=C(N1CCC(C2=NN(CC)C(C3=NC(C4=NN=C(C(C)(C)C)O4)=C(N)N=C3)=N2)CC1)CCO
Molecular Formula
C22H31N9O3
Molecular Weight
469.54
Shipping Conditions
Blue ice
Storage Conditions
Store at -20°C.

Chemical Information

Azd-8835

AZD-8835 is a member of the class of triazoles that is 1H-1,2,4-triazole substituted by ethyl, 1-(3-hydroxypropanoyl)piperidin-4-yl, and 5-amino-6-(5-tert-butyl-1,3,4-oxadiazol-2-yl)pyrazin-2-yl groups at positions 1, 3, and 5, respectively. It is a potent inhibitor of PI3Kalpha and PI3Kdelta (IC50 = of 6.2 and 5.7 nM, respectively) which was in a phase 1 clinical trial for the treatment of advanced solid tumours (trial now discontinued). It has a role as an antineoplastic agent, a bone density conservation agent, an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor and an apoptosis inducer. It is a primary alcohol, a member of triazoles, a member of pyrazines, a member of 1,3,4-oxadiazoles and a N-acylpiperidine.

CAS Number1620576-64-8
PubChem CID76685059
IUPAC Name1-[4-[5-[5-amino-6-(5-tert-butyl-1,3,4-oxadiazol-2-yl)pyrazin-2-yl]-1-ethyl-1,2,4-triazol-3-yl]piperidin-1-yl]-3-hydroxypropan-1-one
Molecular FormulaC22H31N9O3
Molecular Weight469.5
XLogP0.1
Topological Polar Surface Area162
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count10
Rotatable Bond Count7
Heavy Atom Count34
Formal Charge0
Complexity685
SMILES
CCN1C(=NC(=N1)C2CCN(CC2)C(=O)CCO)C3=CN=C(C(=N3)C4=NN=C(O4)C(C)(C)C)N
InChI
InChI=1S/C22H31N9O3/c1-5-31-19(26-18(29-31)13-6-9-30(10-7-13)15(33)8-11-32)14-12-24-17(23)16(25-14)20-27-28-21(34-20)22(2,3)4/h12-13,32H,5-11H2,1-4H3,(H2,23,24)
InChIKey
ZGRDYKFVDCFJCZ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Azd-8835
CAS: 1620576-64-8
CID: 76685059
Formula: C22H31N9O3
MW: 469.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight469.5
XLogP30.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count10
Rotatable Bond Count7
Exact Mass469.25498588
Monoisotopic Mass469.25498588
Topological Polar Surface Area162 Ų
Heavy Atom Count34
Formal Charge0
Complexity685
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
B3224-25AZD3839
A8374-50AZD8330
B3224-10AZD3839
B3224-50AZD3839
A8374-100AZD8330
A8374-5AZD8330
A8214-5.1AZD8055
A8214-100AZD8055
B3224-5AZD3839
A8214-SAZD8055

Alternative Products

CatalogName
MBS579306AZD8835
A16352-25AZD8835 25mg
A16352-50AZD8835 50mg
A16352-10AZD8835 10mg
A16352-100AZD8835 100mg
A16352-5AZD8835 5mg
A16352-10mM-DAZD8835 10mM * 1mL in DMSO

Popular Products