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Raseglurant

CAT: 0804-HY-14866-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14866-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Raseglurant (ADX-10059) is a mGlu5 receptor negative allosteric modulator. Raseglurant is effective against migraine. Raseglurant reduces the Haloperidol -induced catalepsy in mice[1][2].
CAS Number
757950-09-7
Product Name Alternative
ADX-10059
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/raseglurant.html
Purity
99.65
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC1=C(C)C=C(C)N=C1C#CC2=CC=CC(F)=C2
Molecular Formula
C15H13FN2
Molecular Weight
240.28
Precautions
H302, H315, H319, H335
References & Citations
[1]Romero-Fernandez W, et al. The mGlu5 Receptor Protomer-Mediated Dopamine D2 Receptor Trans-Inhibition Is Dependent on the Adenosine A2A Receptor Protomer: Implications for Parkinson's Disease. Mol Neurobiol. 2022 Oct;59 (10) :5955-5969. |[2]Font J, et al. Correction: Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator. Elife. 2018 Jan 8;7:e34752.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Phase 2

Alternative Products

CatalogName
GTR19239328-01Raseglurant

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