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Retigabine

CAT: 0607-B5888-50Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0607-B5888-50Size:50 mg
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Description
An activator of voltage-gated potassium channel, used as an anticonvulsant agent
CAS Number
150812-12-7
Product Name Alternative
(E)-ethyl hydrogen (2-amino-4-((4-fluorobenzyl)amino)phenyl)carbonimidate
Field of Research
Membrane Transporter Ion Channel Potassium Channel
Purity
0.9976
Form
A solid
Solubility
insoluble in H2O; ≥11.1 mg/mL in EtOH with ultrasonic; ≥12.95 mg/mL in DMSO
Smiles
CCO/C(O)=N/C1=C(N)C=C(NCC2=CC=C(F)C=C2)C=C1
Molecular Formula
C16H18FN3O2
Molecular Weight
303.33
Shipping Conditions
Blue ice
Storage Conditions
Store at -20°C.

Chemical Information

Ezogabine

Ezogabine is a substituted aniline that is benzene-1,2,4-triamine bearing ethoxycarbonyl and 4-fluorobenzyl substituents at positions N-1 and N-4 respectively. An anticonvulsant used to treat seizures associated with epilepsy in adults. It has a role as an anticonvulsant and a potassium channel modulator. It is a carbamate ester, an organofluorine compound, a substituted aniline and a secondary amino compound. It is functionally related to a benzene-1,2,4-triamine.

CAS Number150812-12-7
PubChem CID121892
IUPAC Nameethyl N-[2-amino-4-[(4-fluorophenyl)methylamino]phenyl]carbamate
Molecular FormulaC16H18FN3O2
Molecular Weight303.33
XLogP2.8
Topological Polar Surface Area76.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Heavy Atom Count22
Formal Charge0
Complexity348
SMILES
CCOC(=O)NC1=C(C=C(C=C1)NCC2=CC=C(C=C2)F)N
InChI
InChI=1S/C16H18FN3O2/c1-2-22-16(21)20-15-8-7-13(9-14(15)18)19-10-11-3-5-12(17)6-4-11/h3-9,19H,2,10,18H2,1H3,(H,20,21)
InChIKey
PCOBBVZJEWWZFR-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Ezogabine
CAS: 150812-12-7
CID: 121892
Formula: C16H18FN3O2
MW: 303.33
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight303.33
XLogP32.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass303.13830499
Monoisotopic Mass303.13830499
Topological Polar Surface Area76.4 Ų
Heavy Atom Count22
Formal Charge0
Complexity348
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
TRC-R189050-50MGRetigabine
TRC-R189051-100MGRetigabine Dihydrochloride
TMIJ-0074-01Retigabine-d4
C10385-01Retigabine 2HCl
CS-O-43303Retigabine d4

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