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Apatinib

CAT: 0607-B2303-10Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0607-B2303-10Size:10 mg
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Description
VEGFR2 inhibitor, orally bioavailable, selective
CAS Number
1218779-75-9
Product Name Alternative
N-[4-(1-cyanocyclopentyl)phenyl]-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide;methanesulfonic acid
Field of Research
Tyrosine Kinase VEGFR
Purity
0.9985
Form
A solid
Solubility
≥49.4 mg/mL in DMSO; insoluble in H2O; ≥2.17 mg/mL in EtOH with gentle warming and ultrasonic
Smiles
CS(=O)(=O)O.C1CCC(C1)(C#N)C2=CC=C(C=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4
Molecular Formula
C25H27N5O4S
Molecular Weight
493.58
Shipping Conditions
Blue ice
Storage Conditions
Store at -20°C.

Chemical Information

Rivoceranib Mesylate

Rivoceranib Mesylate is the mesylate salt of rivoceranib, an orally bioavailable, small-molecule receptor tyrosine kinase inhibitor with potential antiangiogenic and antineoplastic activities. Rivoceranib selectively binds to and inhibits vascular endothelial growth factor receptor 2, which may inhibit VEGF-stimulated endothelial cell migration and proliferation and decrease tumor microvessel density. In addition, this agent mildly inhibits c-Kit and c-SRC tyrosine kinases.

CAS Number1218779-75-9
PubChem CID45139106
IUPAC NameN-[4-(1-cyanocyclopentyl)phenyl]-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide;methanesulfonic acid
Molecular FormulaC25H27N5O4S
Molecular Weight493.6
Topological Polar Surface Area153
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count6
Heavy Atom Count35
Formal Charge0
Complexity701
SMILES
CS(=O)(=O)O.C1CCC(C1)(C#N)C2=CC=C(C=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4
InChI
InChI=1S/C24H23N5O.CH4O3S/c25-17-24(11-1-2-12-24)19-5-7-20(8-6-19)29-23(30)21-4-3-13-27-22(21)28-16-18-9-14-26-15-10-18;1-5(2,3)4/h3-10,13-15H,1-2,11-12,16H2,(H,27,28)(H,29,30);1H3,(H,2,3,4)
InChIKey
FYJROXRIVQPKRY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Rivoceranib Mesylate
CAS: 1218779-75-9
CID: 45139106
Formula: C25H27N5O4S
MW: 493.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight493.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count6
Exact Mass493.17837553
Monoisotopic Mass493.17837553
Topological Polar Surface Area153 Ų
Heavy Atom Count35
Formal Charge0
Complexity701
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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