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AM251

CAT: 0607-B1427-10Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0607-B1427-10Size:10 mg
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Description
Potent CB1 antagonist
CAS Number
183232-66-8
Product Name Alternative
1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-piperidin-1-ylpyrazole-3-carboxamide
Field of Research
GPCR G protein Cannabinoid Receptor
Purity
0.9864
Solubility
≥55.5 mg/mL in DMSO with gentle warming; insoluble in H2O; ≥6.81 mg/mL in EtOH
Smiles
CC1=C(N(N=C1C(=O)NN2CCCCC2)C3=C(C=C(C=C3)Cl)Cl)C4=CC=C(C=C4)I
Molecular Formula
C22H21Cl2IN4O
Molecular Weight
555.24
Shipping Conditions
Blue ice
Storage Conditions
Store at -20°C.

Chemical Information

N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxamide

AM-251 is a carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor. It has a role as an antidepressant, an antineoplastic agent, an apoptosis inducer and a CB1 receptor antagonist. It is a dichlorobenzene, a member of pyrazoles, a carbohydrazide, an organoiodine compound and an amidopiperidine.

CAS Number183232-66-8
PubChem CID2125
IUPAC Name1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-piperidin-1-ylpyrazole-3-carboxamide
Molecular FormulaC22H21Cl2IN4O
Molecular Weight555.2
XLogP6.5
Topological Polar Surface Area50.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Heavy Atom Count30
Formal Charge0
Complexity585
SMILES
CC1=C(N(N=C1C(=O)NN2CCCCC2)C3=C(C=C(C=C3)Cl)Cl)C4=CC=C(C=C4)I
InChI
InChI=1S/C22H21Cl2IN4O/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-7-16(23)13-18(19)24)21(14)15-5-8-17(25)9-6-15/h5-10,13H,2-4,11-12H2,1H3,(H,27,30)
InChIKey
BUZAJRPLUGXRAB-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxamide
CAS: 183232-66-8
CID: 2125
Formula: C22H21Cl2IN4O
MW: 555.2
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight555.2
XLogP36.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass554.01371
Monoisotopic Mass554.01371
Topological Polar Surface Area50.2 Ų
Heavy Atom Count30
Formal Charge0
Complexity585
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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