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WLB-89462

CAT: 0804-HY-155992-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-155992-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
WLB-89462 (Compound 20c) is a selective σ2 receptor ligand (Ki: 13 nM) . WLB-89462 has neuroprotective activity. WLB-89462 improves short-term memory impairment induced by Aβ peptide in rats. WLB-89462 has good ADMET profile (good solubility, no CYP inhibition, good metabolic stability, high permeability, brain penetration, and high oral exposure in rodents) [1].
CAS Number
2849471-75-4
UNSPSC
12352005
Target
Sigma Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/wlb-89462.html
Purity
98.70
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(CN1CCC(CC1)C2=C(C3=CC(C)=NO3)C=NC(CC)=N2)N4CCOCC4
Molecular Formula
C21H29N5O3
Molecular Weight
399.49
References & Citations
[1]Christmann U, et al. Discovery of WLB-89462, a New Drug-like and Highly Selective σ2 Receptor Ligand with Neuroprotective Properties. J Med Chem. 2023 Sep 14;66 (17) :12499-12519.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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