Neratinib (HKI-272)

• Description:

  HER2/EGFR inhibitor,potent and irreversible

• Product Name Alternative:

  (E)-N-[4-[3-chloro-4-(pyridin-2-ylmethoxy)anilino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide

• Sequence:

  HKI-272;HKI272;HKI 272

• Field of Research:

  JAK STAT Signaling EGFR Tyrosine Kinase EGFR Tyrosine Kinase HER2

• Purity:

  0.9981

• Form:

  A solid

• Solubility:

  insoluble in H2O; ≥13.93 mg/mL in DMSO with gentle warming; ≥2.52 mg/mL in EtOH with gentle warming

• Smiles:

  CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)C#N)NC(=O)C=CCN(C)C

• Molecular Formula:

  C30H29ClN6O3

• Molecular Weight:

  557.04

• Shipping Conditions:

  Blue ice

• Storage Conditions:

  Store at -20°C.

• CAS Number:

  698387-09-6