Raloxifene (hydrochloride)

Raloxifene (hydrochloride)

• CAS Number: 82640-04-8
• UNSPSC Description: Raloxifene hydrochloride (Keoxifene hydrochloride) is a second generation?selective and orally active estrogen receptor modulator. Raloxifene hydrochloride produces estrogen-agonistic effects on bone and lipid metabolism and estrogen-antagonistic effects on uterine endometrium and breast tissue[1].
• Target Antigen: Autophagy; Estrogen Receptor/ERR
• Type: Natural Products
• Related Pathways: Autophagy;Vitamin D Related/Nuclear Receptor
• Field of Research: Endocrinology; Cancer
• Assay Protocol: https://www.medchemexpress.com/raloxifene-hydrochloride.html
• Smiles: O=C(C1=C(C2=CC=C(O)C=C2)SC3=CC(O)=CC=C31)C4=CC=C(OCCN5CCCCC5)C=C4.Cl
• Molecular Weight: 510.04
• References & Citations: [1]Yang, N.N., et al., Estrogen and raloxifene stimulate transforming growth factor-beta 3 gene expression in rat bone: a potential mechanism for estrogen- or raloxifene-mediated bone maintenance. Endocrinology, 1996. 137(5): p. 2075-84.|[2]Obach, R.S., Potent inhibition of human liver aldehyde oxidase by raloxifene. Drug Metab Dispos, 2004. 32(1): p. 89-97.|[3]Sato, M., M.K. Rippy, and H.U. Bryant, Raloxifene, tamoxifen, nafoxidine, or estrogen effects on reproductive and nonreproductive tissues in ovariectomized rats. FASEB J, 1996. 10(8): p. 905-12.|[4]Black, L.J., et al., Raloxifene (LY139481 HCI) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized rats. J Clin Invest, 1994. 93(1): p. 63-9.|[5]Shibata MA, et al. Raloxifene inhibits tumor growth and lymph node metastasis in a xenograft model of metastatic mammary cancer.BMC Cancer. 2010 Oct 19;10:566.Cell Rep Methods. 2023 Oct 23;3(10):100599.|Eberhard Karls Universität Tübingen. 2021 Aug.|Free Radic Biol Med. 2017 Apr 10;108:404-417.|Med Sci Monit. 2019 Apr 29;25:3146-3153.|Oxid Med Cell Longev. 2021 Mar 20;2021:6699054.|PLoS Negl Trop Dis. 2019 Aug 20;13(8):e0007681. |Research Square Preprint. 2020 Nov 4;rs.3.rs-100914.|Viruses. 2021 Jun 28;13(7):1255.|ACS Omega. 2023 Jun 14.|J Pharmaceut Biomed. 2020, 113870.|Mol Neurobiol. 2024 Oct 2.
• Shipping Conditions: Room Temperature